Photocatalytic Technology
Photochemistry is a technique that enables complex organic reactions to be carried out efficiently. However, it is often overlooked by pharmacologists due to the limitations of light absorption as described by the Bouguer-Lambert-Beer law. In order to overcome this limitation, scientists have combined photochemistry with flow chemistry to ensure a uniform irradiation of the narrow channels. In this way, all the reaction mixtures will be uniformly irradiated, whereas in a batch protocol only the outer part of the vessel will receive a sufficient number of photons for the reaction to take effect.
Nowadays, photocatalytic technology is gradually being applied in the production of existing APIs and intermediates. Photocatalysis technology refers to achieve efficient oxidation of saturated carbon-hydrogen bonds in organic compounds under visible light irradiation with the use of cheap and available cerium-based catalysts and reagents. Therefore, high yields of oxidation products can be obtained without the application of expensive precious metal catalysts and high temperature and pressure conditions. Aiming to achieve a more sustainable approach, BOC Sciences has invested significant resources in photochemistry.
Figure 1. An oscillatory plug flow photoreactor facilitates. (Cristian, R.; et al. 2020)
Advantages of photocatalytic technology
- Less consumption of energy and materials in production
- High efficiency
- Low side reactions
- Reduction of pollution emissions
- A small reaction volume can be used for high pressure and high temperature reactions with the advantage of fast and efficient heating and cooling for almost perfect process control and higher conversion rates.
- Mixing of substrate and reagents or quenching of reaction solutions can be performed more efficiently in small volumes
- The flow rate of the substrate and reagent solution determines the residence time inside the reactor, offering the advantage of precise control of the phase contact time under defined physical conditions
- Heterogeneous catalysts can be immobilized inside the small reactor volume with the advantage of less complicated workup and product separation
- In the case of photochemical reactions, small reaction volumes can be fully irradiated within the residence time in the reactor during the residence time in the reactor with the advantage of higher conversion and selectivity due to less over-irradiation and continuous degradation.
Our Services
To make it easier and better for researchers, BOC Sciences provides photocatalytic technology service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.
BOC Sciences is committed to using more sustainable methods, so our team has invested significant resources in photochemistry. Combined with our flow chemistry capabilities, photochemistry offers a green, cost-effective option:
Typical processes in photochemistry
Processes
- Active pharmaceutical intermediates (API)
- API and intermediate synthesis
- API carriers and particle modifications
- API synthesis
Typical Photoreaktor
- Side-Loop Photoreactors
- Plug-Flow Photoreactors
- Agitated Photoreactors
- Falling film type photoreactor
Continuous reaction capabilities
- Ring-opening
- Photo-oxidation
- Photo-redox
Figure 2. Schematic representation of the reaction setup. (Cristian, R.; et al. 2020)
Devices
- High irradiance array LEDs
- Multi-channel multi-spectrum LEDs
- Photo reactors
- Flow PC with laser
- 220V power supply
- Mercury vapor lamp
Why choose BOC Sciences?
Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:
- Comprehensive, integrated CMC services with a flexible service model that grows with your programs
- Knowledgeable industry experts who deliver scalable, actionable insights
- World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
- Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
- A focus on risk management that is designed to ensure completion of your technical goals
BOC Sciences provides professional, rapid and high-quality services of photocatalytic technology at competitive prices for global customers. Personalized and customized services of photocatalytic technology can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
Reference
- Cristian, R.; et al. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C-N couplings. Reaction Chemistry & Engineering. 2020. 5: 597-604.
