Metal Catalysis
A diversity of metal-catalyzed synthesis are widely applied in API processes, providing a cleaner process and therefore greener chemistry. BOC Sciences’ R&D center has established a 24/96-well plated-based micro-metal screening platform, and is dedicated to providing higher-end metal catalyzed DoE services to our customers. The center allows our teams to introduce transition metal catalyst-screening technology to its existing small molecule process development and manufacturing platform. Based on our advanced platform, our teams are able to identify and optimize the optimal conditions for Pd and Cu catalyzed coupling reactions such as Suzuki, Buchwald, Ullman and other types of C-C, C-N bond formation.
Figure 1. Transition Metal Catalysis. (Némethová, I.; R, Ebesta. 2020)
Benefits of metal catalysis
Metal catalysis has several advantages over traditional reactive chemistry:
- Allow for fast reactions, requiring fewer steps than stoichiometric reagents
- Operate at lower temperatures and pressures
- Reduce capital costs and provide a higher degree of safety
Our Services
To make it easier and better for researchers, BOC Sciences provides metal catalysis service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.
- Significantly reduce the amount of sample consumed by employing our metal-catalyzed platform
- Our state-of-the-art facility will allow for rapid screening of metal catalysts, ligands, bases, acids, chemical resolution reagents and amide formation coupling reagents
- The screening kits enable high-throughput screening of metal catalysts and ligands for C-C, C-N, C-O and C-S formation reactions, as well as many other types of reactions, such as chemical resolution and amide formation
- Multiple parallel interactive testing methods are available to find the best catalysts more rapidly
- Provide high rate of throughput to facilitate various process development activities
- Among the transition metals, the platinum group metals (PGMs) are commonly used in drug synthesis. PGMs include ruthenium (Ru), rhodium (Rh), palladium (Pd), osmium (Os), iridium (Ir), and platinum (Pt)
Our capabilities
- Suzuki
- Epoxidation
- H/D isotope exchange
- Hydrocarbon activation
- Transfer hydrogenation
- Asymmetric reactions
- Buchwald/Ullman
- Carbonyl insertion reaction
- Conjugate addition
Figure 2. Heterogeneous chiral Rh catalysts. (Saito, Y.; Shu, K. 2020)
Why choose BOC Sciences?
Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:
- Comprehensive, integrated CMC services with a flexible service model that grows with your programs
- Knowledgeable industry experts who deliver scalable, actionable insights
- World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
- Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
- A focus on risk management that is designed to ensure completion of your technical goals
BOC Sciences provides professional, rapid and high-quality services of metal catalysis at competitive prices for global customers. Personalized and customized services of metal catalysis can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!
References
- Némethová, I.; R, Ebesta. Are Organozirconium Reagents Applicable in Current Organic Synthesis?. Synthesis. 2020. 53(3).
- Saito, Y.; Shu, K. Development of Robust Heterogeneous Chiral Rhodium Catalysts Utilizing Acid-Base and Electrostatic Interactions for Efficient Continuous-Flow Asymmetric Hydrogenations. Journal of the American Chemical Society. 2020. 142(39).
