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Media Formulation Development

Cell matrix refers to all continuous passaged cell lines, diploid cell lines and primary cells of animal or human origin that can be used for biologics production. Cell culture medium is a nutrient base that artificially simulates the in vivo growth environment of animal cells and maintains the survival and proliferation of cells in vitro. Due to the complexity of cell metabolism and different cell lines, time-consuming iterative experiments are required to optimize the media formulation. BOC Sciences provides our customers with optimized solutions to support their specific projects. Through our well-designed media development and optimization platform, we have the ability to provide high-quality media performance strategies.

Our Services

To make it easier and better for researchers, BOC Sciences provides media formulation development service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.We offer a full range of services and flexible options based on our customers' specific requirements, which iare guaranteed by our high-quality systems. We are proud of our successful track record of assisting many customers with media development for their innovative and generic biologics.

  • Proprietary formulation library and experimental design
  • High-throughput screening platform
  • Pre-batch pilot production

Cell culture conditioned  media. Figure 1. Cell culture conditioned media. (Sinha, A.; Principe, S. et al. 2018)

BOC Sciences flexible and complete solutions

The BOC Sciences media services team is capable of providing cell culture solutions based on our customers' unique processing needs, and our scientists can offer services across the entire range of bioprocessing unit operations.

  • Industry leading quality

At BOC Sciences, cell culture media, reagents and buffers are manufactured in compliance with cGMP regulations, and the process begins with approved and specified raw materials obtained from qualified suppliers

  • Customized solutions for unique needs

We offer industry-leading batch size scalability including liquid and powder media and buffers from small scale up to commercial scale. Our packaging solutions are designed to support media, buffers and WFI-quality water programs

  • Comprehensive media optimization services

BOC Sciences offers process-integrated media services that allow our customers to better understand the process and all variables included to improve upstream process and facilitate a shorter time-to-market

  • Media formulation development process
    1. Express platform survey
    2. Technology transfer, gap analysis, media platform screening

    3. Basal and feed media development & optimization
    4. Basal media development, feed media development, flask/bioreactor

    5. Client verification
    6. Flask/bioreactor

Example of cell  media. Figure 2. Example of cell media. (Ackermann, T.; Tardito, S. 2019)

Why choose BOC Sciences?

Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:

  • Comprehensive, integrated CMC services with a flexible service model that grows with your programs
  • Knowledgeable industry experts who deliver scalable, actionable insights
  • World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
  • Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
  • A focus on risk management that is designed to ensure completion of your technical goals

BOC Sciences provides professional, rapid and high-quality services of media formulation development at competitive prices for global customers. Personalized and customized services of media formulation development can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!


  1. Sinha, A.; Principe, S. et al. Proteomic Profiling of Secreted Proteins, Exosomes, and Microvesicles in Cell Culture Conditioned Media. Methods Mol Biol. 2018. 1722: 91-102.\
  2. Ackermann, T.; Tardito, S. Cell culture medium formulation and its implications in cancer metabolism. Trends in Cancer. 2019. 5(6): 329-332.


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