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Continuous Manufacturing Technology

Many pharmaceutical companies apply continuous manufacturing technologies to perform chemical reactions in temperature-controlled pipes or tubes, increasing efficiency, flexibility and the ability to meet the market's rapidly evolving requirements. BOC Sciences is committed to investing in the development of the R&D and production capabilities of continuous manufacturing, working to improve the safety and efficiency of pharmaceutical production, diversifying the types of reactions that can be employed and provide greater flexibility in the design of synthetic routes.

Benefits of Continuous Manufacturing

  • Allow for increased process control
  • More robust, highly automated systems
  • Reduce the need for human handling

Continuous Manufacturing TechnologyFigure 1. Schematic representation of the 'tube-in-tube' reactor. (Baumann, M.; Baxendale, I. R. 2016)

Our Services

To make it easier and better for researchers, BOC Sciences provides continuous manufacturing service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.

  • Continuous flow process is combined with PAT to realize the on-line monitoring
  • Well-established continuous manufacturing laboratories enable the conversion of batch processes for different types of reactions into continuous mode
  • Screening and optimization of continuous manufacturing process parameters
  • Capable of carrying out continuous production in kilogram level
  • Equipped with a wide range of flow reactors (e.g. microchannel reactors, tubular reactors of different materials of construction and small jacketed CSTRs) and modular operating units (e.g. various types of pumps, temperature control units and back pressure regulators)
  • Seamless transfer and scale-up of the flow processes.
  • Successful continuous manufacturing R&D and production projects involving continuous nitrification, ozonolysis, azide reaction, n-BuLi reaction and diazomethane production

Our Expertise in Continuous Manufacturing

Our expertise in route selection and industrial process development allows us to correctly select the most appropriate reactor solution to meet our customers' continuous processing requirements.

Dedicated team

  • Our work in continuous processing is supported by our team who is able to provide our customers with over 20 years of practical flow chemistry experience and expertise

Expertise in hazardous chemistry

  • The flow chemistry solutions we offer are an important complement to our expertise and proven track record in pharmaceutical synthesis and hazardous chemistry

Powerful solutions

  • BOC Sciences supports a wide range of flow-based reactors, and our team is able to design the reactor to contain only a small amount of reactive material for a given period of time. This allows us to provide robust continuous processing solutions that increase production flexibility while improving safety and reducing waste

Continuous development

  • We have successfully handled continuous processing for a range of laboratory-scale development projects, and we are expanding our capabilities to support continuous processing for multi-kilogram and larger manufacturing scales

Selected reactions

  • Low temperature metallo-organic reactions
  • High temperature/pressure reactions
  • Continuous ozonolysis reactions
  • Oxidation with the use of air/oxygen or peroxides
  • Nitrogen rich reactions involving azides or hydrazine
  • Continuous photo reactions
  • Flow hydrogenation
  • Flow nitration
  • Enzymatic reactions using immobilized enzymes

Continuous Manufacturing TechnologyFigure 2. Flow synthesis of rufinamide. (Baumann, M.; Baxendale, I. R. 2016)

Why choose BOC Sciences?

Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:

  • Comprehensive, integrated CMC services with a flexible service model that grows with your programs
  • Knowledgeable industry experts who deliver scalable, actionable insights
  • World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
  • Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
  • A focus on risk management that is designed to ensure completion of your technical goals

BOC Sciences provides professional, rapid and high-quality services of continuous manufacturing technology at competitive prices for global customers. Personalized and customized services of continuous manufacturing technology can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!


  1. Baumann, M.; Baxendale, I. R. The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry. Blstn Journal of Organic Chemistry. 2016. 47(12): 1194.


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