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Enzymes Development

Enzymes are a class of proteins that catalyze biological reactions and are involved in almost all metabolic processes. Enzymes can catalyze a wide variety of reactions in the body by increasing the rate at which biological reactions occur. Organisms themselves can produce multiple kinds of enzymes to increase the rate of an immense and diverse set of chemical reactions required for life. Industrial enzymes have become a widely applied catalyst in various industries and are manufactured to speed up chemical reactions. Scientists extract enzymes from cells, and then utilize them to help complete molecular biology experiments. In an enzymatic reaction, the starting molecule (substrate) is converted into the desired product. Enzymes can catalyze specific reactions by interacting with specific substrates. Enzyme therapies have become increasingly important in the portfolios of pharmaceutical companies. BOC Sciences has invested significant investments in cGMP fermentation capabilities and expertise. Our well-established enzyme platform provides all the resources needed to produce critical medical enzymes, and our experts are dedicated to delivering highly consistent, high-yield enzyme products that can be modified and optimized for the subsequent manufacturing.

Enzyme therapies. Figure 1. Enzyme therapies. (Koeller, K. M.; Wong, C. H. 2001)

Application of Enzymes

  • Enzymes in medical research

Enzymes play an important role in medical research, including new drug development, disease treatment, diagnosis or prognosis. Enzymes can also be applied in assay kits, such as coupled multi-enzyme assay kits and enzyme-linked immunosorbent assay (ELISA) kits, to facilitate testing and diagnosis

  • Enzyme in new drug development

The synthesis and development of chiral molecules is an important part of drug production. Scientists use enzymes extensively to achieve chiral resolution. Due to the high selectivity and specificity of enzymatic reactions, enzymatic routes can yield optical isomers containing both R- and S-configurations

  • Enzymes in therapeutics

Enzymes are specific biocatalysts, which makes them the most desirable therapeutic agents for the treatment of metabolic diseases. For example, asparaginase and glutaminase have been successfully used in the treatment of leukemia, collagenase are applied in the treatment of skin ulcers, and hyaluronidase can play a role in the treatment of heart disease. In addition, advanced genetic engineering techniques can alter the molecules of the enzymes to reduce or even avoid antigenicity. In the future, more potential enzymes drugs will be used to treat cancer and neurology

  • Enzymes in diagnostics

Diagnostic enzymes refer to enzymes used for diagnostic or prognostic. Many enzymes have been used clinically to diagnose bone disease, cancer, and liver disease, including alkaline phosphatase (ALP), acid phosphatase (ACP), and alanine aminotransferase (ALT). Enzymes are also used in analytical and testing processes such as coupled multi-enzyme reaction assays and enzyme-linked immunosorbent assays (ELISA).

Transglutaminase  catalyzed reactions. Figure 2. Transglutaminase catalyzed reactions. (Stenberg, P.; Roth, B. 2015)

Our Services

To make it easier and better for researchers, BOC Sciences provides enzymes development service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs.

  • Raw materials under regulatory conditions in compliance with current Good Manufacturing Practices (cGMP)
  • A diversity of sizes of non-GMP reactors for bioreactor fermentation of enzyme APIs
  • Validation of protein expression
  • Optimization of technology for the production of enzyme APIs
  • Recombinant expression
  • Enzyme evolution
  • Immobilization
  • Downstream processing (spray drying, packaging/drug product/formulation)
  • Enzyme activity
  • Proteins of microbial or mammalian origin

Putative enzymes, antigens  and associated HLA in the five autoimmune diseases.Figure 3. Putative enzymes, antigens and associated HLA in the five autoimmune diseases. (Stenberg, P.; Roth, B. 2015)

Why choose BOC Sciences?

Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:

  • Comprehensive, integrated CMC services with a flexible service model that grows with your programs
  • Knowledgeable industry experts who deliver scalable, actionable insights
  • World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
  • Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
  • A focus on risk management that is designed to ensure completion of your technical goals

BOC Sciences provides professional, rapid and high-quality services of enzymes development at competitive prices for global customers. Personalized and customized services of enzymes development can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!


  1. Koeller, K. M.; Wong, C. H. Enzymes for chemical synthesis. Nature. 2001. 409(6817): 232.
  2. Stenberg, P.; Roth, B. Zinc is the modulator of the calcium-dependent activation of post-translationally acting thiol-enzymes in autoimmune diseases. Medical Hypotheses. 2015. 84: 331-33.


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