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Material Research

The ability to produce stable pharmaceutical ingredients is key to turning promising compounds into effective and safe products. Materials research on active pharmaceutical ingredients (APIs) is indispensable to obtain exploitable solid forms and crystallization processes. Stability, solubility, bioavailability and processability of APIs can be significantly improved. BOC Sciences' materials science team provides comprehensive discovery support services that include solid state chemistry, solid form screening and crystallization process development. Our team specializes in solid state morphology screening and various physicochemical characterization techniques for crystalline forms. Our goal is to help our customers select the best solid form and crystalline development process to progress in preclinical studies and clinical trials.

Material ResearchFigure 1. a) Illustration of the process for sustained drug release from the TA-Ti IV-API crystal composites. b) UV-vis absorption spectra of the caffeine released from the TA-Ti IV-caffeine crystal composite particles over time. c) Graph showing the release profiles of caffeine from the gel-caffeine composites. (Arifur, R. M.; et al.2018)

Our Services

To make it easier and better for researchers, BOC Sciences provides material research service in a competitive fashion. We have provided a more efficient way to increase the number of new drugs, greatly shorten the R&D cycle, and reduce the development costs. Through sound experimental design and efficient execution, as well as extensive experience in solid-state and crystalline form development, we can effectively provide critical scientific data and solutions for each stage of solid-state development spanning preclinical, clinical and commercial.

  • Drug discovery support for initial compound CMC analysis, crystallization, and preclinical formulation
  • Polymorph and salt/co-crystal screening for solid form selection
  • Preformulation for formulation development
  • Crystallization processes for scaling up, controlling polycrystals and particle size of APIs and intermediates
  • Solid-state and physicochemical analysis for compound/material characterization

Material ResearchFigure 2. Illustration of the a) crystallization of the API in the TA-Ti IV gel system and b) sol-gel transition and subsequent crystallization of the API in the gels. (Arifur, R. M.; et al.2018)

Crystallization Process Development

BOC Sciences' crystallization teams are equipped with powder X-ray diffractometer (pXRD), differential scanning calorimeter (DSC), thermal gravimetric analyzer (TGA), polarized light microscopes (PLM), and particle size distribution analyzer (PSD) to support any crystallization process development

Solid State Development

Our solid state chemistry team is able to perform solid state chemistry studies to understand and control the physical properties of the target APIs. Our capabilities include performing salt screening to enhance our in-depth understanding of APIs, and we support high-throughput methods to ensure that a wide range of antagonists and solvents are studied. In addition, we can perform detailed solubility testing to properly select salts for subsequent studies, and BOC Sciences supports polymorph screening to generate a detailed morphology profiles. To ensure that the selected salt and morphology can be generated reproducibly, we have designed a complete crystallization development process

Material ResearchFigure 3.Potential methods for delivering multimodal drug therapy. (Almansa, C.; et al.2019)

Why choose BOC Sciences?

Our dedicated CMC team has provided tailored solutions to our clients from engagement to launch. With many years of industry experience, we provide clients with the following:

  • Comprehensive, integrated CMC services with a flexible service model that grows with your programs
  • Knowledgeable industry experts who deliver scalable, actionable insights
  • World-class facilities and equipment that remain at the forefront of the global pharmaceutical research, analytical and development standards
  • Our comprehensive services support products at every stage of the product lifecycle, from early-stage discovery to full commercial cGMP manufacture
  • A focus on risk management that is designed to ensure completion of your technical goals

BOC Sciences provides professional, rapid and high-quality services of material research at competitive prices for global customers. Personalized and customized services of material research can satisfy any innovative scientific study demands. Our clients have direct access to our staff and prompt feedback to their inquiries. If you are interested in our services, please contact us immediately!


  1. Arifur, R. M.; et al. Supramolecular Metal-Phenolic Gels for the Crystallization of Active Pharmaceutical Ingredients. Small. 2018. e1801202.
  2. Almansa, C.; et al. Co-crystals as a new approach to multimodal analgesia and the treatment of pain. Journal of Pain Research. 2019. 12: 2680-2689.


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